Previously, a series of genes have been identified as causative genes for both epilepsy and NDD, such as GRIN2A, GRIN2B, BCOR, FRMPD4, APC2, NEXMIF, SZT2, SHROOM4, BRWD3, KCNK4, and UNC79 (Liu et al., 2021; Bian et al., 2022; Li et al., 2022, 2023; Yan et al., 2022; Bayat et al., 2023; Jin et al., 2023; Luo et al., 2023; Tian et al., 2023; Wang et al., 2023; Ye et al., 2023). The gene discussed is GRIN2B; the disease is Neurodevelopmental delay.