Some studies suggest that kainate receptors containing the GluK1 subunit represent promising candidates for seizure prevention (Khalilov et al., 2002; Smolders et al., 2002; Rogawski et al., 2003), while others failed to confirm the pharmacological inhibition of GluK1-kainate receptors as an epilepsy treatment strategy (Fritsch et al., 2014). Here, GRIK1 is linked to epilepsy.