AML: acute myeloid leukemia; APL: acute promyelocytic leukemia; N: number of patients; BSA: body surface area; BMI: body mass index; NA: not applicable; ECOG: Eastern Cooperative Oncology Group; H/O/: history of; CNS: central nervous system; Hb: hemoglobin; TLC: total leucocyte count; PS: peripheral smear; BM: bone marrow; MRC: myelodysplasia-related changes; NOS: not otherwise specified; DS: down syndrome; LDH: lactate dehydrogenase; WHO: World Health Organization; ELN: European LeukemiaNet; FAB: French-American-British. The gene discussed is GSTM1; the disease is Down syndrome.