In adults, both these mutations, NPM1 and FLT3 (both ITD & TKD), were more common (22.25% and 27.04%, respectively) than in pediatric patients (Table 1; p <0.001), similar to other studies [23,24]. Double mutations of NPM1 and FLT3-ITD were more common in adults than in pediatric AML cases (1.68% vs. 10.14%, <0.001). This evidence concerns the gene NPM1 and acute myeloid leukemia.