As a result, decisions were made as the following: defining age > 65 years old as advanced age, body temperature > 38.3 °C and <36.0 °C as hyperthermia and hypothermia, WBC > 12.0 or <0.4 × 103/μL and platelet < 100 × 103/μL as sepsis based on the International Guidelines for Management of Severe Sepsis and Septic Shock [61], CRP > 100 mg/dL as severe systemic infection based on previous research [62], and hemoglobin < 8 mg/dL as severe anemia based on the World Health Organization’s guidelines [63] for all the continuous variables. This evidence concerns the gene CRP and anemia (phenotype).