TNNI3 and Sepsis: However, in a retrospective cohort study of patients older than 40 years who survived to hospital discharge after an index hospitalization for sepsis, elevation of cTnI during sepsis identified patients at increased risk for subsequent cardiovascular complications; among 14,046 eligible adults with measured cTnI, 2012 (14.3%) experienced the composite cardiovascular outcome, including 832 (10.9%) patients with normal cTnI levels, compared with 370 (17.3%), 376 (17.6%), and 434 (20.3%) patients within each tertile of sequential abnormal cTnI, respectively (p < 0.001).