For the first time, based on analysis, we found that PLOD2 expression was positively correlated with 12 immune checkpoint genes (BTN2A1, BTN2A2, CD209, CD276, CD47, CD80, CD86, CTLA4, HAVCR2, SIRPA, TIGIT, VYCN1) in patients with HCC. The gene discussed is BTN2A2; the disease is hepatocellular carcinoma.