Shi et al. demonstrated that increased glucose uptake by M2-like tumor-associated macrophages (M2-like TAMs) promoted O-GlcNAcylation of cathepsin B via O-GlcNAc transferase (OGT), which increased mature cathepsin B levels in macrophages and its secretion into the TME, ultimately promoting cancer metastasis and chemoresistance [45]. The gene discussed is CTSB; the disease is neoplasm.