In a study of 118 consecutive biopsy-proven NAFLD cases, Ballestri et al. [18] found that the independent predictors of NASH were waist circumference, HOMA-IR, metabolic syndrome, and circulating levels of alanine aminotransferase (ALT), uric acid, and total cholesterol; the independent predictors of NAS ≥ 5 were serum ALT, uric acid, and total cholesterol levels; the independent predictors of significant and advanced fibrosis were age, waist circumference, metabolic syndrome, serum ALT, total cholesterol, platelet count, HOMA-IR, and T2D. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.