This process activates pathways such as Janus kinase/signal transducers/activators of transcription (JAK-STAT), nuclear factor-kB (NFkB) and p38 mitogen-activated protein kinase pathways [23,24] that decreased creatinine clearance and led to exacerbation of glomerulosclerosis and interstitial fibrosis [25,26]. The gene discussed is NFKB1; the disease is glomerulosclerosis.