In contrast, oxylipins generated through the 12-LOX pathway (12-HETE, 12-HEPE, 14-HDoHE) were significantly lower in ischemia (Isch group) compared with controls (Isch:2.19 ± 0.52, Control: 4.61 ± 0.86 nM, p = 0.017585) (Figure 5C). This evidence concerns the gene SPRR2A and ischemia.