TLR4 and necrotizing enterocolitis: In fact, 2′ fucosyllactose and 6′ sialyllactose, characteristic oligosaccharides of human milk, have the ability to bind directly to TLR4, inhibiting its signaling in cultured enterocytes, in enteroids derived from mouse intestine and in intestinal explants obtained at the time of surgical resection of patients with NEC [29].