PNPLA3 and Hepatic fibrosis: In an observational clinical trial [102], a multivariable logistic regression analysis adjusted for BMI, age, and PNPLA3 (I148M) genotype revealed a significant positive relationship between liver fibrosis and SFA (measured in liver-PL) and a negative relationship between liver fibrosis and PUFA (in liver-PL), MUFA (in liver-TAG), and MUFA (in plasma-TAG).