At the same time, Liu et al. [46] studied CRC-related tumor stem cells, applied fluorescence-activated cell sorting technology, and separated two CSC subsets that expressed epithelial cell adhesion molecules (EpCAMhi) and extracellular matrix receptor III (CD44+) at high levels from the tumor tissues of two patients with primary colon cancer. Here, CD44 is linked to malignant colon neoplasm.