This process is governed by numerous proangiogenic mediators such as vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), metalloproteinases (MMPs), etc., and antiangiogenic factors (endostatin, thrombospondin, angiostatin, etc.)released by endothelial cells, immune cells and tumor stroma cells. The gene discussed is VEGFA; the disease is neoplasm.