The paper “Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors” bases its central hypothesis on the idea that several interrelated factors, such as that the development of non-alcoholic fatty liver disease (NAFLD) in individuals with a genetic susceptibility is influenced by various factors such as insulin resistance, dietary factors, gut microbiota, and genetic and epigenetic factors [77]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.