INS and diabetes mellitus: For more than five decades, the relationship between the emergence of resistance to insulin and accumulation of abdominal fat tissue tissue and atherosclerosis has been researched and highlighted by a multitude of studies showing both the increased incidence of diabetes and other pathological conditions specific to metabolic syndrome, elevated levels of low-density lipoprotein cholesterol (LDL), decreased levels of high-density lipoprotein cholesterol (HDL), and hypertension (high blood pressure) and high uric acid.