CD8A and neoplasm: Low CDKN1B expression was significantly correlated with low lymphocyte-infiltrating signature scores (p < 0.001), decreased B cells (p < 0.001), decreased CD8+ T cells (p = 0.04), high tumor cell proliferation (p = 0.04), low leukocyte count (p < 0.001), and elevated M2 macrophages (p < 0.001) (Figure 3B).