Since aberrant changes in the most abundant 18.5 kDa isoform of MBP in adult humans and bovines [9,10,11] weaken MBP-membrane interactions and disrupt myelin integrity [12], MBP is addressed as a possible autoantigen in multiple sclerosis (MS) [7,13,14], a chronic immune and neurodegenerative disease [15,16] manifested through CNS inflammation, oligodendrocyte loss, or axonal degeneration. The gene discussed is MBP; the disease is neurodegenerative disease.