Another study using TaqMan qMSP in fecal samples from Chinese patients with CRC has determined differences in methylation for other genes, such as collagen type IV alpha 1 and alpha 2 chain (COL4A1, COL4A2), T-cell leukemia homeobox protein 2 (TLX2), and integrin subunit alpha 4 (ITGA4) [58]. This evidence concerns the gene TLX2 and colorectal carcinoma.