Other genes under consideration as a CRC biomarker for American and Chinese patients are Wnt inhibitory factor 1 (WIF-1) [36,37] and vimentin (VIM), which codifies an intermediate filament protein that is not methylated in normal colonic epithelial cells but becomes methylated in 53–83% of CRC tissues [38]. Here, WIF1 is linked to colorectal carcinoma.