MTHFR and esophageal cancer: In the paper by Tian et al., who published a metanalysis of GWAS and esophageal cancer, variants in five genes were associated with EAC [24]; none of them are localized on chromosome 5p (ERCC2(a), GSTP1(p), hOGG1(p), MTHFR(p), and CCND1(a)), and the missense exonic variants of these genes present in our patient were always reported as benign.