Godler and coworkers [5] evaluated differential alterations in the mRNA levels of UBE3A and SNORD116 located within the 15q11–q13 region between Chromosome 15-imprinting disorders (Prader–Willi (PWS), Angelman (AS) and chromosome 15 duplication (Dup15q) syndromes) and their subtypes in correlation with clinical phenotypes. This evidence concerns the gene UBE3A and Prader-Willi syndrome.