While the neuroprotective effects of LY 379268 and JNJ-46281222 have been explored in the literature and their therapeutic potential for neurodegenerative diseases investigated, our data are the first to demonstrate that THRX-195518, acting as a mGlu2 PAM, may also be a potential drug molecule with neuroprotective potential against Glu toxicity. This evidence concerns the gene GRM2 and neurodegenerative disease.