TNF and cancer: Among these proteins, c-FLIP (Cellular FLICE Inhibitory Protein) is a major anti-apoptotic and resistance protein, restraining apoptosis induced by the TNF (Tumor Necrosis Factor) superfamily members, including TRAIL (TNF-Related Apoptosis Inducing Ligand), Fas-Ligand or TNFα, as well as apoptosis stimulated by chemotherapeutic drugs in cancer cells [4].