IGF2BP3 and cancer: Previous studies reported that ICD and its derivatives can inhibit cancer cell proliferation through many pathways, such as the induction of G2/M cell cycle arrest and apoptosis [23], a reduction in insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression [24] the downregulation of ITGA1 expression [25], and the regulation of apoptotic process PDCD4 expression [26].