The effectiveness of the association of 2-AEH2P has been investigated in association with other compounds, seeking to identify its pharmacological action; with the BR2 tumor penetration peptide, the modulation of proteins involved in cell death, such as p53, Bax, Bad, Bcl-2, caspase 3 and 8, was observed with cytochrome C release and senescence with increased p21 and reduced cyclin D1 and markers of progression and invasiveness, CD44, CD34, CD24 for triple-negative MDA MB-231 human breast adenocarcinoma cells [18]. The gene discussed is CASP3; the disease is neoplasm.