NOS2 and cancer: Enzymes such as inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, glutathione peroxidase (GPx), NADPH oxidase, high-mobility group box 1 (HMGB1), and superoxide dismutase (SOD) are among those whose abnormal activation has been linked to the development of inflammation-related diseases, including cancer and cardiovascular disease [77].