HDL, owing to their antioxidant activity attributed by enzymes such as paraoxonase 1 (PON-1), lecithin-cholesterol acyltransferase (LACT), and platelet-activating factor acetyl hydrolase (PAF-AH), inhibit and prevent the LDL oxidation [8] and the consequent impact on atherosclerosis. Here, PON1 is linked to atherosclerosis.