In addition, hypermethylation of CpG islands in the promoters of the genes involved in transcriptional regulation and microsatellite instability, mainly associated with mutations in the BRAF gene, the TGF-β receptor type II gene and the pro-apoptotic bcl-2-like protein 4 (BAX) gene, may contribute to the development of CRC [8]. This evidence concerns the gene BAX and colorectal carcinoma.