In the study developed by Amorim et al. (2020) [24], it was also demonstrated that the rutin flavonoid can reduce the proliferation of tumor cells, as well as induce the chemotaxis of microglia to the tumor microenvironment in monocultures of cells of the C6 lineage, stimulate the upregulation of tumor necrosis factor (TNF) expression, and reduce the expression of cytokines and chemokines such as IL-10, MCI, and growth factors (IGF, GDNF). This evidence concerns the gene IGF1 and neoplasm.