We also investigated the effects of this indirect interaction in the expression of cytokines IL-6, IL-10, IL-1β, and TNF-α, and in the STAT3 signaling protein in microglia subjected to a conditioned medium containing secretome from GBM cells treated or untreated with rutin, as well as under more homeostatic control conditions. The gene discussed is STAT3; the disease is glioblastoma.