Additionally, it has been reported that HMGB1 initiates neurite degeneration in the AD brain by phosphorylating TLR4-myristoylated alanine-rich C-kinase substrate (MARCKS) and induces Aβ oligomers and protofibrils, exacerbating AD’s pathology [16]. The gene discussed is TLR4; the disease is Alzheimer disease.