CFL1 and intracerebral hemorrhage: In the mouse model of intracerebral hemorrhage (ICH), inhibition of cofilin by cofilin siRNA before the experimental induction of the ICH showed a remarkable improvement of sensorimotor tests and attenuated cofilin expression, hematoma volume, brain edema, BBB impairment, microglia activation, apoptosis, and oxidative and nitrosative stress [150].