In addition, a study showed that injected Adeno-associated viruses (AAVs) encoded with asparagine endopeptidase (AEP)-induced cofilin 1–138 mutant led to a reduction in pathological tau and cognitive deficit compared with the control group (injected with AVVs encoded with wild-type cofilin) in a mouse model of AD (tau-P301S) [58]. This evidence concerns the gene CFL1 and Cognitive impairment.