PROM1 and Alzheimer disease: Freshly sorted acinar cells (UEA-1+CLA−CD133−), ductal cells (UEA-1−CLA+CD133+), and cultured AD cells (acinar cells that have undergone ADM) (UEA-1+CLA−CD133+) were subjected to RNA-seq analysis [29], which revealed five gene clusters with distinct expression patterns (Figure 1A, K means cluster = 5).