Recently, it has been shown that infection of GD-SH-01 or the HEP-Flury recombinant strain carrying GD-SH-01 P gene (rHEP-shP) results in the downregulation of Bcl-2, a decrease in mitochondrial membrane potential, an increase in mitochondrial cytochrome c release, and the activation of caspase-9 and caspase-3 [27,126]. This evidence concerns the gene CYCS and infection.