Indeed, N-cadherin expression was suggested to facilitate the escape of tumor cells from the control of resident keratinocytes in the epidermis [51,52,53], providing them an invasive behavior favored by the homophilic interactions with fibroblasts or endothelial cells in the tumor microenvironment [51,54], and also promoting cell survival and migration [55]. This evidence concerns the gene CDH2 and neoplasm.