Sotiropoulos et al., Xu et al.: higher serum chemerin levels in patients with NSCLC compared to controls but controversy over the association between chemerin levels, lymph node involvement and tumoral stage [71,72].Li F. et al.: no difference in serum chemerin levels between NSCLC patients and controls [73].Zhao S. et al., Cai et al.: association between increased chemerin expression by tumor cells in lung slides from patients with NSCLC and good prognosis [74,75].Zhao H. et al.: association between higher expression of RARRES2 in patients with NSCLC and good prognosis [76]. This evidence concerns the gene RARRES2 and neoplasm.