Omori et al.: contraction of isolated pulmonary arteries induced by chemerin and greater effect on arteries isolated from PAH rats [69]. Hanthazi et al.: potentiation of vasoconstrictor effects and antagonization of vasodilatator effects by chemerin [70].Peng et al.: upregulation of chemerin and CMKLR1 expression by isolated smooth muscle cells if exposed to recombinant chemerin or hypoxia. Migration and proliferation of these cells by chemerin [67]. Here, CMKLR1 is linked to pulmonary arterial hypertension.