In conclusion, our data identify a three-phasic inflammation during retinal degeneration and scar formation, detect significant changes in gene expression of ECM-related genes during retinal wound healing with Col4α3, ICAM1, fibulin1, itgal and selp as involved key genes, and shows that pirfenidone reduces the expression of ECM proteins and inflammatory markers but may not prevent long-term fibrotic responses. This evidence concerns the gene ITGAL and retinal degeneration.