However, data reported in our study indicate that a functional nuclear lamina is necessary to properly arrange cytoplasmic intermediate filaments in response to mechanical stretching, while alterations of this mechanism occurring in LMNA-mutated myoblasts impair nuclear positioning already in mononucleated muscle precursors and could be crucial to the onset of skeletal muscle defects observed in laminopathies. This evidence concerns the gene LMNA and laminopathy.