PPARGC1A and breast carcinoma: Conflicting results regarding PGC-1α were found in breast cancer, where lower gene expression of PGC-1α was affiliated with lower survival patient rate and worse disease prognosis [60], while in vitro PGC-1α activation stimulated mitochondrial biogenesis and OXPHOS leading to increased invasive and metastatic potential of breast cancer cells [61,62].