To evaluate the influence of sclerostin on tumor cell proliferation, the two OSCC tumor cell lines SCC-040 and PCI-13 were treated with different concentrations (1 ng/mL, 5 ng/mL, and 10 ng/mL) of rh-sclerostin for different time periods (24 h, 36 h, 48 h, 60 h, and 72 h). This evidence concerns the gene SOST and neoplasm.