Since the multifaceted properties of tumor cells depend on the spaciotemporal expressions of small G-proteins, such as Ras, Rap, and Rho, whose functions are inexorably linked to farnesyl and/or geranylgeranyl-groups derived from metabolites in the mevalonate pathway, tumor cells might contain an elevated level of IPP/DMAPP, which can be recognized by γδ T cells [49]. This evidence concerns the gene RHO and neoplasm.