In this case, the evaluation covered temozolomide-conjugated gold nanoparticles functionalized with an antibody against the EPHA3 (anti-EPHA3-TMZ@GNP) via intranasal administration bypassing the blood–brain barrier (BBB) in a Sprague Dawley rat orthotopic GBM tumour model [163]. The gene discussed is EPHA3; the disease is glioblastoma.