The significant new properties of nucleic acid-based aptamer have also provided new insights regarding the role of EPHA2 in the pathogenesis of GBM, where targeting EPHA2 by two aptamer agents, such as 40L and its truncated form A40s, resulted in the inhibition of cell growth and the migration of GBM stem-like cells [120]. The gene discussed is EPHA2; the disease is glioblastoma.