While it is well-documented that the activation of the NF-κB pathway in inflammatory cells, such as T cells and monocytes, contributes to the development of MS and EAE by fostering inflammation [120,125,132,133,134], there is intriguing evidence suggesting a protective role for NF-κB activation in oligodendrocytes against inflammation in these conditions [120]. Here, NFKB1 is linked to myeloid sarcoma.