PGF and preeclampsia: Mayer-Pickel et al. showed that 75–150 mg/day aspirin overall did not affect the plasma sFlt1/PlGF ratio throughout gestation in women regardless of obstetric outcomes, although there appeared to be a transient reduction of the sFlt1/PlGF ratio at 11–14 weeks gestation, but not later, in a subset women with a pathologic first-trimester screening for preeclampsia risk [26].