Notch1 and its ligand Jagged1 have been implicated in post-ischaemic neovascularisation in both experimental and clinical stroke, where increases in the expression of activated Notch1 (Notch intracellular domain or NICD) in peri-infarct endothelial cells are coupled with the level of angiogenesis [107]. This evidence concerns the gene NOTCH1 and stroke disorder.