Therefore, when CD8+ T cells of the immunized mice infiltrate into the tumors and secret the large amounts of IFN-γ in response to the tumor cells, it is possible that the large amounts of secreted IFN-γ can spread into wide areas of the tumors and convert the immunosuppressive TAM to the pro-inflammatory M1-type macrophages and effectively suppress the tumor growth. This evidence concerns the gene CD8A and neoplasm.