Topical treatments with Ozoile in patients with balanitis xerotica obliterans (BXO) have shown an anti-inflammatory and tissue-regenerating effect by reducing the mRNA levels of pro-inflammatory cytokines IL-1β, TNF-α, INF-γ, transglutaminase 2 and NOS2, as well as increasing the expression of hypoxia-inducible factor (HIF)-1alpha, vascular endothelial growth factor (VEGF), and E-cadherin gene expression [16]. Here, VEGFA is linked to penile disorder.