In contrast to the triple wild-type (BRAF wild-type, NRAS wild-type, and NF1 wild-type) melanomas and the BRAF- and NRAS-mutated melanomas, NF1-mutated melanomas have a strong association with ultraviolet (UV) damage, as evidenced histologically by a higher degree of background solar elastosis in the dermis [18]. This evidence concerns the gene NRAS and melanoma.