Sepsis and ARDS together can cause endothelial damage in veins, microcirculation, and capillary extravasation due to the induction of the vascular endothelial growth factor (VEGF) and nitric oxide (NO), modifying the volume of distribution and, consequently, the pharmacokinetics of antibiotics such as ceftriaxone [5]. The gene discussed is VEGFA; the disease is Sepsis.