Analysis of the expression and activation of ERK1/2 in CCD841 normal colon cells, DLD1 colon adenocarcinoma cells, and aggressive HCT116 colon carcinoma cells suggested downregulation of both the phosphorylation and the expression of total ERK1/2 proteins in DLD1 and HCT116 cells (Figure 2b). Here, MAPK3 is linked to colon carcinoma.