By analyzing the cBioPortal database, we found that mutations to Ser in USP14 occurred in skin cutaneous melanoma, uterine endometrioid carcinoma, prostate adenocarcinoma, and ovarian cancer, and the mutation of Lys to other amino acids i GPX4 was detected in colorectal cancer (Figure 7E). The gene discussed is GPX4; the disease is colorectal cancer.