PIP, as well, has been reported to be a potent inhibitor of NF-κB translocation in melanoma [80] and to attenuate cigarette-smoke-induced oxidative stress and lung inflammation by upregulating Sirtuin1 (SIRT1) and promoting the inhibition of NF-κB and the activation of the antioxidant response via nuclear factor erythroid 2-related factor 2 (Nrf2) [81]. The gene discussed is SIRT1; the disease is melanoma.