The association of PNPLA3 I148M with MAFLD was independently confirmed a few years later [95] and in numerous studies which have gone on to link the variant to important liver disease phenotypes, including elevated serum transaminases [92,96], liver fibrosis [96,97,98], and hepatocellular carcinoma [99]. Here, PNPLA3 is linked to Hepatic fibrosis.